![]() ![]() Because these reactions are reported voluntarily from a population The following adverse reactions have been identifiedĭuring postapproval use of Imitrex Tablets, Imitrex Nasal Spray, and Imitrex Vomiting (4% Imitrex, 0% placebo), and bronchospasm (1% Imitrex, 0% placebo). The trials of cluster headache was generally lower than in the migraine trials.Įxceptions include reports of paresthesia (5% Imitrex, 0% placebo), nausea and Overall, the frequency of adverse reactions reported in ![]() Identified in trials of Imitrex in patients with migraine. New significant adverse reactions were detected that had not already been Of Imitrex Injection as a treatment for cluster headache (Studies 4 and 5), no In the controlled clinical trials assessing the efficacy Insufficient data to assess the impact of race on the incidence of adverse ![]() Trials was not affected by gender or age of the patients. The incidence of adverse reactions in controlled clinical Stinging/burning, swelling, erythema, bruising, bleeding. Placebo-Controlled Trials in Patients with Migraine (Studies 2 and 3) That occurred at a frequency greater than the placebo group are included in Only reactions that occurredĪt a frequency of 2% or more in groups treated with Imitrex Injection 6 mg and Single 6-mg dose of Imitrex Injection or placebo. Table 1 lists adverse reactions that occurred in 2 US placebo-controlledĬlinical trials in migraine patients (Studies 2 and 3) following either a Varying conditions, adverse reaction rates observed in the clinical trials of aĭrug cannot be directly compared with rates in the clinical trials of anotherĭrug and may not reflect the rates observed in practice. Chest, throat, neck, and/or jaw pain/tightness/pressureīecause clinical trials are conducted under widely.Myocardial ischemia, myocardial infarction, and Prinzmetal's angina.The following serious adverse reactions are described Imitrex (sumatriptan) side effects list for healthcare professionals Infant exposure may be reduced by avoiding breastfeeding for 12 hours after administration of Imitrex. Safe use of Imitrex in pregnancy has not been established. Serious side effects of Imitrex are rare and include:ĭrug interactions of Imitrex include monoamine oxidase inhibitors ( MAOIs), which may reduce the breakdown of Imitrex in the liver leading to increased blood levels and side effects of Imitrex.Ĭombining Imitrex with sibutramine, selective serotonin reuptake inhibitors (SSRIs), or serotonin and norepinephrine reuptake inhibitors (SNRIs) may increase the concentration of serotonin in the brain, causing increased serotonin-related side effects.Īdministering Imitrex within 24 hours of treatment with an ergot-containing medication is contraindicated because such combinations increase the likelihood of vasospasms. pain or tightness in the chest or throat,.Imitrex does not prevent or reduce the number of headaches. At the same time, it also reduces transmission of pain signals by nerves to the brain. Imitrex relieves migraines by stimulating serotonin receptors in the brain which cause the muscles surrounding the blood vessels in the brain to contract and narrow the blood vessels. Migraine headaches are believed to result from dilatation of blood vessels in the brain. Imitrex ( sumatriptan) is a selective serotonin receptor agonist (a “triptan”) used to treat migraine headaches. ![]()
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